HOE 239
Fexinidazole
CAS: 59729-37-2
Molecular Formula: C12H13N3O3S
HOE 239 - Names and Identifiers
| Name | Fexinidazole |
| Synonyms | HOE239 HOE-239 HOE 239 Fexinidazole Fexinidazole (HOE 239) 1-Methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole |
| CAS | 59729-37-2 |
HOE 239 - Physico-chemical Properties
| Molecular Formula | C12H13N3O3S |
| Molar Mass | 279.319 |
| Storage Condition | Room Temprature |
| Use | Introduction: A DNA synthesis inhibitor developed by the neglected diseases drug program in collaboration with Sanofi for oral treatment of human African trypanosomiasis (HAT) and Chagas disease and is the first full oral treatment, both for the first stage of the HAT and for the worm crossing the blood-brain barrier, the second stage of neuropsychiatric symptoms in the patient. Non-cotinidazole is a 5-nitroimidazole derivative originally discovered by HoechstAG and identified as active against Trypanosoma brucei and Trypanosoma roxburghii by DNDi in 2005. |
HOE 239 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.58 ml | 17.901 ml | 35.801 ml |
| 5 mM | 0.716 ml | 3.58 ml | 7.16 ml |
| 10 mM | 0.358 ml | 1.79 ml | 3.58 ml |
| 5 mM | 0.072 ml | 0.358 ml | 0.716 ml |
Last Update：2024-01-02 23:10:35
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